PODBrowser is a desktop application written in Python that previews Microsoft Excel spreadsheets (versions: 2003, 2002, XP, 2000, 97, 95, 5.0, 4.0, 3.0) and produces Probability Of Detection (POD) plots from the data.  Chances are you’re not terribly interested in POD or nondestructive evaluation, but you might want to have a look if you are interested in delivering standalone wxPython, matplotlib, and NumPy applications.  Among other things, there’s a custom wxPython spreadsheet control, an Excel to ASCII text converter, and a “open with default application” utility in there.

Also check out Delivering wxPython Applications With PyInstaller if you’re interested in distributing Python apps as .EXEs for Windows users.